Macrolide-resistant Streptococcus pyogenes in Norway: population structure and resistance determinants

P Littauer; D A Caugant; M Sangvik; E A Høiby; A Sundsfjord; G S Simonsen

doi:10.1128/AAC.50.5.1896-1899.2006

Macrolide-resistant Streptococcus pyogenes in Norway: population structure and resistance determinants

Antimicrob Agents Chemother. 2006 May;50(5):1896-9. doi: 10.1128/AAC.50.5.1896-1899.2006.

Authors

P Littauer¹, D A Caugant, M Sangvik, E A Høiby, A Sundsfjord, G S Simonsen

Affiliation

¹ Department of Microbiology and Infection Control, University Hospital of North Norway and Department of Microbiology and Virology, Faculty of Medicine, Institute for Medical Biology, University of Tromsø, N-9037 Tromsø, Norway. Pia.Littauer@unn.no

Abstract

A 2.7% prevalence of macrolide resistance in 1,657 Norwegian clinical Streptococcus pyogenes isolates was primarily due to erm(TR) (59%) and mef(A) (20%). Four clonal complexes comprised 75% of the strains. Macrolide resistance in S. pyogenes in Norway is imported as resistant strains or locally selected in internationally disseminated susceptible clones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Drug Resistance, Bacterial / genetics*
Genes, Bacterial
Macrolides / therapeutic use*
Norway / epidemiology
Prevalence
Selection, Genetic
Sequence Analysis, DNA
Streptococcal Infections / drug therapy
Streptococcal Infections / epidemiology
Streptococcal Infections / microbiology
Streptococcus pyogenes / drug effects*
Streptococcus pyogenes / genetics
Streptococcus pyogenes / isolation & purification

Substances

Macrolides