Quantification of ion-induced molecular fragmentation of isolated 2-deoxy-D-ribose molecules

Phys Chem Chem Phys. 2006 Apr 28;8(16):1922-8. doi: 10.1039/b517109a. Epub 2006 Mar 14.

Abstract

Recent experiments on low energy ion-induced damage to DNA building blocks indicate that ion induced DNA damage is dominated by deoxyribose disintegration (Phys. Rev. Lett., 2005, 95, 153201). We have studied interactions of keV H+ and He(q+) with isolated deoxyribose molecules by means of high resolution time-of-flight spectrometry. Extensive statistical fragmentation of the molecules is observed. The fragment distribution is found to follow a power law dependence. The exponent can be used to characterize and quantify the molecular damage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Damage*
  • DNA Fragmentation*
  • Data Interpretation, Statistical
  • Deoxyribose / analysis*
  • Deoxyribose / chemistry
  • Deoxyribose / isolation & purification
  • Ions*
  • Models, Chemical
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*

Substances

  • Ions
  • Deoxyribose