DNA repair: DNA polymerase zeta and Rev1 break in

Nadine K Kolas; Daniel Durocher

doi:10.1016/j.cub.2006.03.043

DNA repair: DNA polymerase zeta and Rev1 break in

Curr Biol. 2006 Apr 18;16(8):R296-9. doi: 10.1016/j.cub.2006.03.043.

Authors

Nadine K Kolas¹, Daniel Durocher

Affiliation

¹ Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

PMID: 16631579
DOI: 10.1016/j.cub.2006.03.043

Abstract

DNA polymerase zeta and Rev1 play key roles in replication past DNA lesions. New work shows that the yeast checkpoint kinase Mec1 recruits a complex consisting of polymerase zeta and Rev1 to DNA double-strand breaks. This study highlights the role of polymerases that mediate translesion synthesis in the response to DNA double-strand breaks.

MeSH terms

DNA Repair / physiology*
DNA, Fungal / biosynthesis*
DNA-Directed DNA Polymerase / physiology
Intracellular Signaling Peptides and Proteins
Nucleotidyltransferases / physiology*
Protein Serine-Threonine Kinases
Saccharomyces cerevisiae / physiology*
Saccharomyces cerevisiae Proteins / physiology*

Substances

DNA, Fungal
Intracellular Signaling Peptides and Proteins
Saccharomyces cerevisiae Proteins
MEC1 protein, S cerevisiae
Protein Serine-Threonine Kinases
DNA polymerase zeta
Nucleotidyltransferases
REV1 protein, S cerevisiae
DNA-Directed DNA Polymerase