Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome

Biljana Jekic; Ivana Novakovic; Ljiljana Lukovic; Milos Kuzmanovic; Branka Popovic; Jelena Milasin; Gordana Bunjevacki; Tatjana Damnjanovic; Suzana Cvjeticanin; Vera Bunjevacki

doi:10.1016/j.cancergencyto.2005.11.003

Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome

Cancer Genet Cytogenet. 2006 Apr 15;166(2):163-5. doi: 10.1016/j.cancergencyto.2005.11.003.

Authors

Biljana Jekic¹, Ivana Novakovic, Ljiljana Lukovic, Milos Kuzmanovic, Branka Popovic, Jelena Milasin, Gordana Bunjevacki, Tatjana Damnjanovic, Suzana Cvjeticanin, Vera Bunjevacki

Affiliation

¹ Institute of Biology and Human Genetics, School of Medicine, 26 Visegradska Str., 11000 Belgrade, Serbia and Montenegro. biljanaj@verat.net

PMID: 16631474
DOI: 10.1016/j.cancergencyto.2005.11.003

Abstract

Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisms underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed mutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9 showed no mutations in the analyzed sequences. Our results suggest that molecular mechanisms of MDS evolution in children are different from those in adults.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child, Preschool
Codon / genetics
Cohort Studies
DNA Mutational Analysis
DNA, Neoplasm / genetics
Exons / genetics
Genes, fms / genetics*
Genes, p53 / genetics*
Humans
Mutation / genetics*
Myelodysplastic Syndromes / genetics*
Polymorphism, Single-Stranded Conformational

Substances

Codon
DNA, Neoplasm