Cushing syndrome with secondary adrenal insufficiency from concomitant therapy with ritonavir and fluticasone

Susan R Johnson; Alicia A Marion; Teri Vrchoticky; Patricia J Emmanuel; Jorge Lujan-Zilbermann

doi:10.1016/j.jpeds.2005.11.034

Cushing syndrome with secondary adrenal insufficiency from concomitant therapy with ritonavir and fluticasone

J Pediatr. 2006 Mar;148(3):386-8. doi: 10.1016/j.jpeds.2005.11.034.

Authors

Susan R Johnson¹, Alicia A Marion, Teri Vrchoticky, Patricia J Emmanuel, Jorge Lujan-Zilbermann

Affiliation

¹ Division of Infectious Diseases, Department of Pediatrics, University of South Florida College of Medicine, Tampa, 33606, USA. sjohnso2@hsc.usf.edu

PMID: 16615973
DOI: 10.1016/j.jpeds.2005.11.034

Abstract

We present 2 cases of Cushing syndrome with secondary adrenal insufficiency from concomitant use of ritonavir and inhaled corticosteroids in children with human immunodeficiency virus infection. These cases highlight the need for special consideration when treatment with an inhaled/intranasal corticosteroid is indicated in children receiving antiretroviral therapy.

Publication types

Case Reports

MeSH terms

Administration, Inhalation
Adolescent
Adrenal Insufficiency / chemically induced*
Albuterol / administration & dosage
Albuterol / adverse effects
Albuterol / analogs & derivatives
Androstadienes / administration & dosage
Androstadienes / adverse effects*
Asthma / drug therapy
Bronchodilator Agents / administration & dosage
Bronchodilator Agents / adverse effects*
Child
Cushing Syndrome / chemically induced*
Drug Interactions
Drug Therapy, Combination
Female
Fluticasone
HIV Infections / drug therapy
HIV Protease Inhibitors / administration & dosage
HIV Protease Inhibitors / adverse effects*
Humans
Ritonavir / administration & dosage
Ritonavir / adverse effects*
Salmeterol Xinafoate

Substances

Androstadienes
Bronchodilator Agents
HIV Protease Inhibitors
Salmeterol Xinafoate
Fluticasone
Ritonavir
Albuterol