Highly enantioselective addition of Me2Zn to aldehydes catalyzed by ClCr(Salen)

Pier Giorgio Cozzi; Peter Kotrusz

doi:10.1021/ja057969d

Highly enantioselective addition of Me2Zn to aldehydes catalyzed by ClCr(Salen)

J Am Chem Soc. 2006 Apr 19;128(15):4940-1. doi: 10.1021/ja057969d.

Authors

Pier Giorgio Cozzi¹, Peter Kotrusz

Affiliation

¹ Dipartimento di Chimica, University of Bologna, G. Ciamician, via Selmi 2, 40126 Bologna, Italy. piergiorgio.cozzi@unibo.it

PMID: 16608313
DOI: 10.1021/ja057969d

Abstract

High enantiomeric excesses are obtained in the addition of Me2Zn catalyzed by commercially available ClCr(Salen). Broad scope, simple procedure, room temperature, low catalyst loading are the characteristics of this new enantioselective process, which uses the rather unreactive Me2Zn. Enantiomeric excesses in the range of 71-99% are obtained with all the aldehydes tested.