The study evaluated the influence of atenolol/nifedipine on the local anaesthesia with lidocaine in 64 patients with essential arterial hypertension following dietetic regimen and divided in: control group (21 patients), atenolol-treated group (21 patients with atenolol therapy) and nifedipine-treated group (22 patients with nifedipine therapy). Atenolol/nifedipine was administrated three hours before anaesthesia (1.5 mg lidocaine/kg body weight) applied on Spix Spina. The atenolol/nifedipine influence on the anaesthetic intensity was evaluated both by the patient and dentist using scales for the appreciation of pain intensity (Visual Analogue Scale, Numerical Rating Scale) at 0 minutes (before anaesthesia), 5, 10, 20, 30, 60 minutes (moments for the determination of lidocaine plasmatic concentrations). There were no statistically significant differences between the values appreciated by the patient and dentist. Our data demonstrated a significant decrease of pain intensity in patients treated with atenolol/nifedipine. Very good inverse correlation was found between lidocaine concentrations and pain intensity.