Abstract
Stressor induces not only cognitive, emotional and behavioral changes but also autonomic changes. Although research on the neural circuits underlying such autonomic changes has implicated the hypothalamus in the defense response against stressors, neurotransmitters in this multifaceted and coordinated response have not been revealed. In this brief review, here we summarize our recent discovery using orexin knockout mice and orexin neuron-ablated mice of possible contribution of orexin in the defense response and discuss future directions.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Behavior, Animal / physiology
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Blood Pressure / drug effects
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Blood Pressure / physiology
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Defense Mechanisms*
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Heart Rate / drug effects
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Heart Rate / physiology
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Hypothalamus / metabolism
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Intracellular Signaling Peptides and Proteins / deficiency
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Intracellular Signaling Peptides and Proteins / metabolism*
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Mice
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Mice, Knockout
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Models, Biological
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Neurons / metabolism*
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Neurons / pathology
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Neuropeptides / deficiency
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Neuropeptides / metabolism*
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Orexins
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Reaction Time / genetics
Substances
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Intracellular Signaling Peptides and Proteins
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Neuropeptides
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Orexins