Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes

Nalan Gündoğdu-Karaburun; Kadriye Benkli; Yağmur Tunali; Umit Uçucu; Seref Demirayak

doi:10.1016/j.ejmech.2005.12.013

Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes

Eur J Med Chem. 2006 May;41(5):651-6. doi: 10.1016/j.ejmech.2005.12.013. Epub 2006 Mar 22.

Authors

Nalan Gündoğdu-Karaburun¹, Kadriye Benkli, Yağmur Tunali, Umit Uçucu, Seref Demirayak

Affiliation

¹ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. ngundogd@anadolu.edu.tr

PMID: 16554110
DOI: 10.1016/j.ejmech.2005.12.013

Abstract

In this study, some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketones, aryl (3-methyl-benzofuran-2-yl) ketoximes and aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketoximes were synthesised starting from 2-aryloyl-3-methyl-benzofuranes. The structure elucidation of the compounds was performed by IR, 1H-NMR, MASS spectroscopy and elemental analyses. Antifungal activities of the compounds were examined and moderate activity was obtained.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Azoles / chemistry*
Benzofurans / chemistry*
Candida / drug effects
Imidazoles / chemistry*
Methylation
Molecular Structure
Oximes / chemical synthesis
Oximes / chemistry*
Oximes / pharmacology*
Structure-Activity Relationship

Substances

Antifungal Agents
Azoles
Benzofurans
Imidazoles
Oximes
imidazole
benzofuran