Single-molecule force spectroscopy of bimolecular reactions: system homology in the mechanical activation of ligand substitution reactions

Farrell R Kersey; Wayne C Yount; Stephen L Craig

doi:10.1021/ja058516b

Single-molecule force spectroscopy of bimolecular reactions: system homology in the mechanical activation of ligand substitution reactions

J Am Chem Soc. 2006 Mar 29;128(12):3886-7. doi: 10.1021/ja058516b.

Authors

Farrell R Kersey¹, Wayne C Yount, Stephen L Craig

Affiliation

¹ Department of Chemistry and Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, North Carolina 27708-0346, USA.

PMID: 16551077
DOI: 10.1021/ja058516b

Abstract

The mechanochemistry of the bimolecular nucleophilic substitution of DMSO for substituted pyridines at a square-planar pincer Pd(II) center was investigated using single-molecule force spectroscopy (SMFS). The SMFS data are interpreted in terms of the Bell-Evans model, which gives thermal off-rates for two reactions that agree well with previous, stress-free measurements. The characteristic force dependency of the rupture rate, fbeta, is effectively constant for the two reactions examined (22 +/- 2 and 24 +/- 2 pN), and the system homology in the mechanical response is consistent with expected similarities in the reaction potential energy surfaces.