Abstract
Mutations in CIAS1/cryopyrin are linked to several autoinflammatory diseases. In this issue of Immunity, a critical role for cryopyrin in the caspase-1/IL-1beta axis and reveal a broader role for cryopyrin than anticipated is uncovered.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Carrier Proteins / physiology*
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Caspase 1 / physiology*
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Enzyme Activation
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Immunity, Innate*
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Interleukin-1 / physiology
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Mice
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NLR Family, Pyrin Domain-Containing 3 Protein
Substances
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Carrier Proteins
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Interleukin-1
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NLR Family, Pyrin Domain-Containing 3 Protein
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Nlrp3 protein, mouse
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Caspase 1