Neurofibromatosis (NF) is a group of heterogeneous multisystemic neurocutaneous disorders that may affect any organ in the body and clinical presentation depends on the body system involved. We present a case of a middle-aged male who presented with a relatively fast growing abdominal mass in the hypogastric and right inguinal area, associated with diarrhea. At laparotomy, a large, solid mass was found in the lower mesentery with loops of small intestine adherent to it. Mass was removed in total along with the loops of intestine and was found to be neurofibroma of mesentery on histopathology.