Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions

Eugene V Babaev; Natalya I Vasilevich; Anna S Ivushkina

doi:10.1186/1860-5397-1-9

Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions

Beilstein J Org Chem. 2005 Oct 7;1(1):9. doi: 10.1186/1860-5397-1-9.

Authors

Eugene V Babaev¹, Natalya I Vasilevich, Anna S Ivushkina

Affiliation

¹ Department of Chemistry, Moscow State University, 119992, Moscow, Russia. babaev@org.chem.msu.su

Abstract

2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.