The objective of this study is to describe the job stress models and non-work stressors, their influence on health and magnitude in Spain. Data come from scientific publications, reports and official statistics, primarily of the last decade. Moreover, original data are provided from the analysis of the 5th Spanish Working Conditions Survey. Job stress analysis is based on two complementary models, that based on psychological demands, control and social support (Karaseks model) and another based on the effort-reward unbalance (Siegrists model). In Spain 15% of men and 22% of women have had an excessive workload that have made them feel tired in the last three months. A quarter of workers have low autonomy and 48% of men and 32% of women work in occupations that do not require special abilities, just experience. Moreover, Spain has the highest unemployment and temporary contracts rates in the 15-European Union. The entrance of women into the labour market implies difficulties in reconciling job and family life. Moreover, paid work provides women with power and economic autonomy, therefore making possible the divorce that has significantly increased in Spain as well as the lonely parents families, these being difficult and stressing situations. Additionally the higher economic autonomy and power among women is considered as one of the causes of the gender violence as well. Response to stress-related problems derived from the globalisation, the increasing importance of the tertiary sector and other social changes is insufficient either because health professionals ignore the causes of the problem and treat pharmacologically the consequences or because health consequences of these new social and economic tendencies are not taken into account in other sectors.