Abstract
Gigantol (1) and 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2) from the orchid Scaphyglottis livida induced a significant concentration-dependent relaxation of the contractions evoked by noradrenaline (NA) in endothelium-intact and denuded rat aorta rings. Incubation with N(G)-nitro-L-arginine methyl ester (L-NAME, 1x10(-5) M) or methylene blue (MB, 1x10(-7) M) significantly reduced the relaxation induced by the stilbenoids 1 and 2. The results suggested that two or more mechanisms are involved in the vasorelaxant effects of both compounds.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta / drug effects*
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Bibenzyls
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Guaiacol / analogs & derivatives*
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Guaiacol / chemistry
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Guaiacol / pharmacology
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Male
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Medicine, Traditional
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Orchidaceae / chemistry*
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Phenanthrenes / chemistry
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Phenanthrenes / pharmacology*
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Rats
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Rats, Wistar
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Sodium / pharmacology
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Stilbenes / chemistry
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Stilbenes / pharmacology*
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Vasodilation / drug effects*
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Vasodilator Agents / pharmacology*
Substances
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3,7-dihydroxy-2,4-dimethoxyphenanthrene
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Bibenzyls
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Phenanthrenes
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Stilbenes
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Vasodilator Agents
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gigantol
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Guaiacol
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Sodium