Endothelium-independent relaxation of aorta rings by two stilbenoids from the orchids Scaphyglottis livida

Fitoterapia. 2006 Apr;77(3):236-9. doi: 10.1016/j.fitote.2006.02.006. Epub 2006 Feb 23.

Abstract

Gigantol (1) and 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2) from the orchid Scaphyglottis livida induced a significant concentration-dependent relaxation of the contractions evoked by noradrenaline (NA) in endothelium-intact and denuded rat aorta rings. Incubation with N(G)-nitro-L-arginine methyl ester (L-NAME, 1x10(-5) M) or methylene blue (MB, 1x10(-7) M) significantly reduced the relaxation induced by the stilbenoids 1 and 2. The results suggested that two or more mechanisms are involved in the vasorelaxant effects of both compounds.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / drug effects*
  • Bibenzyls
  • Guaiacol / analogs & derivatives*
  • Guaiacol / chemistry
  • Guaiacol / pharmacology
  • Male
  • Medicine, Traditional
  • Orchidaceae / chemistry*
  • Phenanthrenes / chemistry
  • Phenanthrenes / pharmacology*
  • Rats
  • Rats, Wistar
  • Sodium / pharmacology
  • Stilbenes / chemistry
  • Stilbenes / pharmacology*
  • Vasodilation / drug effects*
  • Vasodilator Agents / pharmacology*

Substances

  • 3,7-dihydroxy-2,4-dimethoxyphenanthrene
  • Bibenzyls
  • Phenanthrenes
  • Stilbenes
  • Vasodilator Agents
  • gigantol
  • Guaiacol
  • Sodium