Influence of liposphere preparation on butyl-methoxydibenzoylmethane photostability

Eur J Pharm Biopharm. 2006 Jun;63(2):140-5. doi: 10.1016/j.ejpb.2006.01.007. Epub 2006 Mar 13.

Abstract

The incorporation of butyl-methoxydibenzoylmethane (BMDBM), one of the most efficient and frequently used UV-A blockers, into lipospheres was examined in order to decrease the light-induced sunscreen degradation. Lipospheres, obtained by the melt technique and using tristearin as the lipid material and hydrogenated phosphatidylcholine as the emulsifier, showed proper features in terms of size (10-40 microm), BMDBM loading level (21.63% +/- 0.90%, w/w) and physical state. Photolysis studies, involving irradiation of lipospheres with simulated sunlight before and after their introduction in emulsion formulations, demonstrated a relevant enhancement of the encapsulated sunscreen photostability in comparison with unencapsulated BMDBM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry*
  • Calorimetry, Differential Scanning
  • Chalcones / chemistry*
  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Lipids / chemistry*
  • Microscopy, Electron, Scanning
  • Photochemistry*
  • Propiophenones

Substances

  • Alkanes
  • Chalcones
  • Lipids
  • Propiophenones
  • avobenzone