Syntheses of new peptidic glycoclusters derived from beta-alanine: di- and trimerized glycoclusters and glycocluster-clusters

Koji Sato; Noriyasu Hada; Tadahiro Takeda

doi:10.1016/j.carres.2006.02.015

Syntheses of new peptidic glycoclusters derived from beta-alanine: di- and trimerized glycoclusters and glycocluster-clusters

Carbohydr Res. 2006 May 22;341(7):836-45. doi: 10.1016/j.carres.2006.02.015. Epub 2006 Mar 13.

Authors

Koji Sato¹, Noriyasu Hada, Tadahiro Takeda

Affiliation

¹ Kyoritsu University of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.

PMID: 16530741
DOI: 10.1016/j.carres.2006.02.015

Abstract

Fluorescence-labeled glycoclusters 1 and 2 have been synthesized to elongate glycocluster units that contain beta-alanine derivative 6 and sugar unit 7. Similarly, di- and trimerized glycoclusters 3 and 4 have been obtained by coupling glycocluster 17 with succinyl chloride and/or trimesoyl chloride, respectively. Furthermore, glycocluster-cluster 5 was also synthesized by a convergent growth approach.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Conformation
Carbohydrate Sequence
Carbohydrates / chemistry
Carboxylic Acids / chemistry
Dendrimers / chemistry
Dimerization
Glycopeptides / chemical synthesis*
Nuclear Magnetic Resonance, Biomolecular
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tricarboxylic Acids / chemistry
beta-Alanine / chemistry*

Substances

Carbohydrates
Carboxylic Acids
Dendrimers
Glycopeptides
Tricarboxylic Acids
beta-Alanine