Abstract
Uridine 5'-hexadecylphosphate (UMPC16) inhibited the growth of Saccharomyces cerevisiae under a hypersaline stress condition with Na+ more strongly than the calcineurin inhibitor cyclosporine A (CsA). Additional Ca2+ supplementation similarly suppressed the inhibitory activities of UMPC16 and CsA on yeast cell growth in a medium with Na+. UMPC16, but not CsA, accelerated mitochondrial reactive oxygen species (ROS) generation in combination with Na+, suggesting its inhibition of a Ca2+ -dependent but calcineurin-independent mechanism for protection against Na+ toxicity.
MeSH terms
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Calcineurin Inhibitors
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Calcium / pharmacology*
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Cyclosporine / antagonists & inhibitors
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Cyclosporine / pharmacology
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Mitochondria / metabolism
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Osmotic Pressure
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Oxidative Stress* / drug effects
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Reactive Oxygen Species / metabolism
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Saccharomyces cerevisiae / drug effects*
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Saccharomyces cerevisiae / physiology*
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Sodium / antagonists & inhibitors
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Sodium / toxicity*
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Uridine Monophosphate / analogs & derivatives
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Uridine Monophosphate / antagonists & inhibitors
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Uridine Monophosphate / pharmacology
Substances
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Calcineurin Inhibitors
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Reactive Oxygen Species
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uridine 5'-hexadecylphosphate
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Cyclosporine
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Sodium
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Uridine Monophosphate
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Calcium