Configurational analysis of cubebins and bicubebin from Aristolochia lagesiana and Aristolochia pubescens

Inara C de Pascoli; Isabele R Nascimento; Lucia M X Lopes

doi:10.1016/j.phytochem.2006.01.019

Configurational analysis of cubebins and bicubebin from Aristolochia lagesiana and Aristolochia pubescens

Phytochemistry. 2006 Apr;67(7):735-42. doi: 10.1016/j.phytochem.2006.01.019. Epub 2006 Feb 28.

Authors

Inara C de Pascoli¹, Isabele R Nascimento, Lucia M X Lopes

Affiliation

¹ Instituto de Química, Universidade Estadual Paulista, UNESP, C.P. 355, 14801-970, Araraquara, São Paulo, Brazil.

PMID: 16500688
DOI: 10.1016/j.phytochem.2006.01.019

Abstract

(8S,8'R,9S)-, (8R,8'R,9R)-, and (8R,8'R,9S)-cubebins, together with (8R,8'R,8''R,8'''R,9R,9''S)-bicubebin, were isolated from Aristolochia lagesiana and Aristolochia pubescens. Their structures were determined by spectroscopic methods, including 1H and 13C NMR spectroscopy at low temperatures, and by chemical transformations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

4-Butyrolactone / chemistry
4-Butyrolactone / pharmacology
Aristolochia / chemistry*
Circular Dichroism
Lignans / chemistry*
Lignans / isolation & purification
Lignans / pharmacology
Magnetic Resonance Spectroscopy
Molecular Conformation
Plant Extracts / chemistry*
Plants, Medicinal*

Substances

Lignans
Plant Extracts
cubebin
4-Butyrolactone