Gastroesophageal reflux and laryngeal cancer: causation or association? A critical review

Am J Otolaryngol. 2006 Mar-Apr;27(2):119-28. doi: 10.1016/j.amjoto.2005.07.010.

Abstract

Gastroesophageal reflux disease has been implicated as a causative factor in several laryngeal disorders. Its involvement in laryngeal cancer is of interest not only from a clinicopathologic aspect, but also from a public health perspective. However, despite a number of studies, a causal relationship with laryngeal cancer is uncertain. In this article, we address the current literature in a critical manner to facilitate the understanding of this subject and evaluate the relationship between gastroesophageal reflux disease and laryngeal carcinoma.

Publication types

  • Review

MeSH terms

  • Alcohol Drinking / adverse effects
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / epidemiology
  • Humans
  • Laryngeal Neoplasms / epidemiology
  • Laryngeal Neoplasms / etiology*
  • Prevalence
  • Risk Factors
  • Smoking / adverse effects