Biomarkers of OH radical damage in vivo

Free Radic Res Commun. 1991:12-13 Pt 1:11-6. doi: 10.3109/10715769109145762.

Abstract

Mechanisms of formation of o-tyrosine (o-Tyr) and thymine glycol (TG), the two possible markers of OH radical generation in biosystems and in vivo are described. The o-Tyr measurements require invasive approaches, while TG detection may be accomplished by noninvasive analysis in the urine.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biomarkers
  • DNA / drug effects
  • Free Radicals
  • Hydroxides / toxicity*
  • Hydroxyl Radical
  • Hydroxylation
  • Phenylalanine / drug effects
  • Proteins / drug effects
  • Thymine / analogs & derivatives*
  • Thymine / metabolism
  • Thymine Nucleotides / metabolism
  • Tyrosine / metabolism*

Substances

  • Biomarkers
  • Free Radicals
  • Hydroxides
  • Proteins
  • Thymine Nucleotides
  • thymine glycol
  • Hydroxyl Radical
  • Tyrosine
  • Phenylalanine
  • 2-tyrosine
  • DNA
  • Thymine