Abstract
Mechanisms of formation of o-tyrosine (o-Tyr) and thymine glycol (TG), the two possible markers of OH radical generation in biosystems and in vivo are described. The o-Tyr measurements require invasive approaches, while TG detection may be accomplished by noninvasive analysis in the urine.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Biomarkers
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DNA / drug effects
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Free Radicals
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Hydroxides / toxicity*
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Hydroxyl Radical
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Hydroxylation
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Phenylalanine / drug effects
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Proteins / drug effects
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Thymine / analogs & derivatives*
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Thymine / metabolism
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Thymine Nucleotides / metabolism
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Tyrosine / metabolism*
Substances
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Biomarkers
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Free Radicals
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Hydroxides
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Proteins
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Thymine Nucleotides
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thymine glycol
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Hydroxyl Radical
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Tyrosine
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Phenylalanine
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2-tyrosine
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DNA
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Thymine