Abstract
With the increasing incidence of drug-induced liver disease, attempts are being made to better understand the mechanisms behind these frequently life-endangering reactions. Analgesics and anti-inflammatory drugs are a major group exhibiting hepatotoxicity. We review research relating to these reactions, focusing on ultrastructural findings, which may contribute to the comprehension and possible avoidance of drug-induced liver disease. We also present some original observations on clinical material and cultured cells exposed to acetaminophen alone or in combination with the antioxidant N-acetylcysteine or the P-glycoprotein inhibitor verapamil.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors
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Acetaminophen / adverse effects
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Acetaminophen / toxicity
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Acetylcysteine / adverse effects
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Acetylcysteine / toxicity
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Analgesics, Non-Narcotic* / adverse effects
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Analgesics, Non-Narcotic* / toxicity
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Animals
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Anti-Inflammatory Agents, Non-Steroidal* / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal* / toxicity
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Antioxidants / adverse effects
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Antioxidants / toxicity
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Aspirin / adverse effects
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Aspirin / toxicity
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Cell Line, Tumor
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Chemical and Drug Induced Liver Injury
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Drug Overdose
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Hepatocytes / ultrastructure*
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Humans
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Liver / pathology
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Liver / ultrastructure*
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Liver Diseases / pathology*
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Liver Neoplasms / pathology
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Liver Neoplasms / ultrastructure
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Verapamil / adverse effects
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Verapamil / toxicity
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Analgesics, Non-Narcotic
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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Acetaminophen
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Verapamil
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Aspirin
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Acetylcysteine