We investigate the locality of interactions in hydrodynamic turbulence using data from a direct numerical simulation on a grid of 1024(3) points; the flow is forced with the Taylor-Green vortex. An inertial range for the energy is obtained in which the flux is constant and the spectrum follows an approximate Kolmogorov law. Nonlinear triadic interactions are dominated by their nonlocal components, involving widely separated scales. The resulting nonlinear transfer itself is local at each scale but the step in the energy cascade is independent of that scale and directly related to the integral scale of the flow. Interactions with large scales represent 20% of the total energy flux. Possible explanations for the deviation from self-similar models, the link between these findings and intermittency, and their consequences for modeling of turbulent flows are briefly discussed.