Abstract
There has been studied the influence of a number of nonsteroidal antiinflammatory agents (NSAID ) on the humoral immune response of mice in immunization with erythrocytic and viral antigen. It has been found out that NSAID have immunomodulating effect, stimulating humoral immune response (4-iodantipyrine, 4-bromantipyrine) or suppressing it (butadione, sodium salicylate). Apparently the mechanism of NSAID ++ immunostimulating effect is related to the inhibition of T-suppressors ++ function by the latter ones.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adjuvants, Immunologic
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Antibody-Producing Cells / cytology*
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Antibody-Producing Cells / drug effects
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Antigens, Heterophile / immunology*
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Antigens, Viral / immunology*
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Enterovirus / immunology*
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In Vitro Techniques
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Mice
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Sheep
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Spleen / cytology*
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Spleen / drug effects
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
Substances
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Adjuvants, Immunologic
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Anti-Inflammatory Agents, Non-Steroidal
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Antigens, Heterophile
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Antigens, Viral