Functional and evolutionary analyses on expressed intronless genes in the mouse genome

Kishore Ramaji Sakharkar; Meena Kishore Sakharkar; Cymbeline T Culiat; Vincent T K Chow; Shazib Pervaiz

doi:10.1016/j.febslet.2006.01.070

Functional and evolutionary analyses on expressed intronless genes in the mouse genome

FEBS Lett. 2006 Feb 20;580(5):1472-8. doi: 10.1016/j.febslet.2006.01.070. Epub 2006 Jan 31.

Authors

Kishore Ramaji Sakharkar¹, Meena Kishore Sakharkar, Cymbeline T Culiat, Vincent T K Chow, Shazib Pervaiz

Affiliation

¹ National University Medical Institutes, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

PMID: 16469316
DOI: 10.1016/j.febslet.2006.01.070

Abstract

Using computational approaches we have identified 2017 expressed intronless genes in the mouse genome. Evolutionary analysis reveals that 56 intronless genes are conserved among the three domains of life--bacteria, archea and eukaryotes. These highly conserved intronless genes were found to be involved in essential housekeeping functions. About 80% of expressed mouse intronless genes have orthologs in eukaryotic genomes only, and thus are specific to eukaryotic organisms. 608 of these genes have intronless human orthologs and 302 of these orthologs have a match in OMIM database. Investigation into these mouse genes will be important in generating mouse models for understanding human diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Databases, Nucleic Acid
Evolution, Molecular*
Genes / physiology
Genome*
Humans
Introns
Mice / genetics*
Sequence Homology
Species Specificity