The early loss of permanent teeth following trauma or congenital aplasia and agenesia need to be corrected by orthodontic or prosthetic means, sometimes combined with implant therapy. Preprosthetic orthodontic measures are often an integral part of comprehensive oral rehabilitation. The individual aspects of treatment are aimed at optimizing dentofacial esthetics and at improving masticatory function and hygiene potential of prosthetic restorations. The orthodontic solution results usually in different anatomic, functional, and esthetic problems. In the present study the treatment possibilities of two patients with missing upper lateral incisors are presented. In the first case the problem of the missing upper lateral incisors was solved by adhesive bridges, after the fixed appliance orthodontic treatment, where the diasthema medianum was closed, and the upper canines were distalized. In our second case the same problem was solved by inserting implants, with single, metal free crowns in the upper lateral incisor area, after the fixed appliance orthodontic treatment, where the upper canines were distalized, and the bicuspids derotated. Prosthetic and implant procedures are very demanding and require long-term maintenance. Preprosthetic orthodontics will continue to gain significance in future esthetically-functionally oriented dentistry and that its integration into multidisciplinary rehabilitation is often indispensable.