Solid-phase synthesis of biologically interesting compounds containing hydroxamic acid moiety

Mini Rev Med Chem. 2006 Jan;6(1):27-36. doi: 10.2174/138955706775197811.

Abstract

Chemical strategies developed for the solid-phase synthesis of hydroxamates are divided into four groups: (i) the traditional synthesis of hydroxamates via cleavage of resin-bound esters by hydroxylamine and its derivatives, (ii) introduction of hydroxamic acid moiety on the resin-bound precursor, (iii) transformation of polymer-supported hydroxylamine, attached to a solid supported linker either by oxygen (O-linking strategy) or by nitrogen (N-linking strategy), and (iv) synthesis of N-alkyl hydroxamates. The scope and limitation of individual approaches are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arylsulfonates / chemical synthesis
  • Carboxylic Acids / chemistry
  • Combinatorial Chemistry Techniques / methods*
  • Deferoxamine / chemical synthesis
  • Hydroxamic Acids / chemical synthesis*
  • Hydroxamic Acids / chemistry
  • Hydroxylamine / chemistry
  • Molecular Structure
  • Siderophores / chemical synthesis
  • beta-Lactams / chemical synthesis

Substances

  • Arylsulfonates
  • Carboxylic Acids
  • Hydroxamic Acids
  • Siderophores
  • beta-Lactams
  • Hydroxylamine
  • Deferoxamine