Antimalarial activity of methylpiperazinyl-substituted benzophenone-based farnesyltransferase inhibitors

Pharmazie. 2006 Jan;61(1):63-5.

Authors

K Kettler¹, J Wiesner, R Ortmann, H M Dahse, H Jomaa, M Schlitzer

Affiliation

¹ Department für Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Germany.

PMID: 16454209

No abstract available

MeSH terms

Animals
Antimalarials / chemical synthesis*
Antimalarials / pharmacology*
Benzophenones / pharmacology*
Cell Survival / drug effects
Enzyme Inhibitors / pharmacology*
Farnesyltranstransferase / antagonists & inhibitors*
Glutathione Transferase / metabolism
HeLa Cells
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
Piperazines / pharmacology*
Plasmodium falciparum / drug effects
Plasmodium falciparum / growth & development
Structure-Activity Relationship

Substances

Antimalarials
Benzophenones
Enzyme Inhibitors
Indicators and Reagents
Piperazines
Glutathione Transferase
Farnesyltranstransferase