The sum of the lower incisor tooth width has been proposed as the best predictor for calculating unerupted canine and premolar mesiodistal tooth sizes. The aims of this study were to develop a new, fast, and accurate computerized method to predict unerupted mesiodistal tooth sizes and to determine which reference tooth or combination of reference teeth was the best predictor for canines and premolars in a Spanish sample. The dental casts of 100 Spanish adolescents with permanent dentition were measured to the nearest 0.05 mm with a two-dimensional computerized system. The goal was to predict unerupted canine and premolar mesiodistal tooth sizes using the sizes of the upper central incisor, upper and lower first molar, or a combination of these as a reference and using a specific mesiodistal tooth-size table. The results showed that the Digital Method proposed was very accurate in predicting unerupted canine and premolar tooth size. The combination of the sums of the permanent upper central incisor and the lower first molar was the best predictor for canines and premolars in this sample. Upper arch teeth were better predicted than lower arch teeth. The upper lateral incisor provided the worst predictions.