Abstract
Tigecycline, the first-in-class glycylcycline, was developed to recapture the broad spectrum of activity of the tetracycline class and to treat patients with difficult-to-treat bacterial infections. Tigecycline's in vitro spectrum of activity encompasses aerobic, facultative and anaerobic Gram-positive and -negative bacteria, including antimicrobial-resistant bacteria such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Enterococcus faecium, and extended-spectrum beta-lactamase-producing Enterobacteriaceae. Clinical trials involving patients with complicated skin and skin-structure infections and complicated intra-abdominal infections, including patients infected with methicillin-resistant S. aureus, demonstrated that tigecycline was bacteriologically and clinically effective with mild-to-moderate gastrointestinal adverse events (i.e., nausea, vomiting and diarrhea) the most commonly reported. Tigecycline is a promising new broad-spectrum parenteral monotherapy for the treatment of patients with Gram-positive and -negative bacterial infections.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Anti-Bacterial Agents* / adverse effects
-
Anti-Bacterial Agents* / chemistry
-
Anti-Bacterial Agents* / pharmacology
-
Anti-Bacterial Agents* / therapeutic use
-
Bacteria, Aerobic / drug effects
-
Bacteria, Anaerobic / drug effects
-
Clinical Trials as Topic
-
Drug Resistance, Bacterial
-
Female
-
Gastrointestinal Diseases / drug therapy
-
Gastrointestinal Diseases / microbiology
-
Gram-Negative Bacteria / drug effects
-
Gram-Negative Bacterial Infections / drug therapy*
-
Gram-Negative Bacterial Infections / microbiology
-
Gram-Positive Bacteria / drug effects
-
Gram-Positive Bacterial Infections / drug therapy*
-
Gram-Positive Bacterial Infections / microbiology
-
Humans
-
Male
-
Microbial Sensitivity Tests
-
Middle Aged
-
Minocycline / adverse effects
-
Minocycline / analogs & derivatives*
-
Minocycline / chemistry
-
Minocycline / pharmacology
-
Minocycline / therapeutic use
-
Skin Diseases, Bacterial / drug therapy
-
Skin Diseases, Bacterial / microbiology
-
Tigecycline
-
Treatment Outcome
Substances
-
Anti-Bacterial Agents
-
Tigecycline
-
Minocycline