Wortmannilactones A-D, 22-membered triene macrolides from Talaromyces wortmannii

J Nat Prod. 2006 Jan;69(1):128-30. doi: 10.1021/np0502894.

Abstract

The fungus Talaromyces wortmannii, isolated from a soil sample collected in China's Yunnan province, produced four novel 22-membered macrolides, namely, wortmannilactones A-D (1-4). Structures 1-4 were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Compounds 1-4 exhibited in vitro cytotoxic activity against several human cancer cell lines with IC50 values ranging from 28.7 to 130.5 microM.

MeSH terms

  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / isolation & purification
  • Antineoplastic Agents* / pharmacology
  • China
  • Drug Screening Assays, Antitumor
  • Humans
  • Inhibitory Concentration 50
  • Macrolides* / chemistry
  • Macrolides* / isolation & purification
  • Macrolides* / pharmacology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Talaromyces / chemistry*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Macrolides