Abstract
The fungus Talaromyces wortmannii, isolated from a soil sample collected in China's Yunnan province, produced four novel 22-membered macrolides, namely, wortmannilactones A-D (1-4). Structures 1-4 were elucidated by extensive 1D and 2D NMR and MS spectral analyses. Compounds 1-4 exhibited in vitro cytotoxic activity against several human cancer cell lines with IC50 values ranging from 28.7 to 130.5 microM.
MeSH terms
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / isolation & purification
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Antineoplastic Agents* / pharmacology
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China
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Drug Screening Assays, Antitumor
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Humans
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Inhibitory Concentration 50
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Macrolides* / chemistry
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Macrolides* / isolation & purification
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Macrolides* / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Talaromyces / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Macrolides