A study on chirality in biomolecules: the effect of the exchange of L: amino acids to D: ones in Sso7d ribonuclease

J Mol Model. 2006 Mar;12(4):462-7. doi: 10.1007/s00894-005-0073-z. Epub 2006 Jan 19.

Abstract

In this work, the conformational behavior of ribonuclease Sso7d is studied as a function of chirality of its constituting amino acids. Both optimized structures (using molecular mechanics with the CHARMM force field) and dynamic behavior (obtained by molecular dynamic simulations) are compared.

MeSH terms

  • Amino Acids / chemistry*
  • Amino Acids / metabolism*
  • Binding Sites
  • Models, Molecular
  • Protein Structure, Tertiary
  • Ribonucleases / chemistry*
  • Ribonucleases / classification
  • Ribonucleases / metabolism*
  • Stereoisomerism
  • Structural Homology, Protein

Substances

  • Amino Acids
  • Ribonucleases