Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin

Georgios Chamilos; Russell E Lewis; Dimitrios P Kontoyiannis

doi:10.1128/AAC.50.2.744-747.2006

Inhibition of Candida parapsilosis mitochondrial respiratory pathways enhances susceptibility to caspofungin

Antimicrob Agents Chemother. 2006 Feb;50(2):744-7. doi: 10.1128/AAC.50.2.744-747.2006.

Authors

Georgios Chamilos¹, Russell E Lewis, Dimitrios P Kontoyiannis

Affiliation

¹ Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Abstract

Among the Candida species, Candida parapsilosis has a unique mitochondrial respiratory network. The addition of inhibitors of the respiratory pathways in three clinical isolates of C. parapsilosis with high (> or =2- microg/ml) MICs of caspofungin significantly (fivefold) decreased caspofungin MICs but did not change fluconazole MICs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology*
Candida / drug effects*
Candida / metabolism
Caspofungin
Echinocandins
Lipopeptides
Microbial Sensitivity Tests
Mitochondria / drug effects*
Mitochondria / metabolism
Oxygen Consumption / drug effects*
Peptides, Cyclic / pharmacology*

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Peptides, Cyclic
Caspofungin