Abstract
The authors assessed the ability of the neurophilin compound, timcodar dimesylate, to accelerate the return of epidermal nerve fiber density (ENFD) after a standardized nerve injury in a randomized double blind, placebo controlled trial. While there was no difference in the regeneration rate between the treatment and placebo arms, the baseline ENFD (p = 0.006), height (p = 0.02), and race (p = 0.03) were associated with the regeneration rate.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Biopsy
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Double-Blind Method
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Epidermis / innervation*
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Female
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Humans
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Male
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Middle Aged
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Nerve Fibers / pathology
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Nerve Regeneration / drug effects*
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Pain Threshold
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Peripheral Nerve Injuries*
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Peripheral Nerves / pathology
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Peripheral Nerves / physiopathology
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Pyridines / therapeutic use*
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Sensory Thresholds
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Thigh
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Touch
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Wounds and Injuries / drug therapy
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Wounds and Injuries / pathology
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Wounds and Injuries / physiopathology