[Human brucellosis in Lebanon. Clinical features and therapeutic responses in 88 patients]

J Med Liban. 2004 Jul-Sep;52(3):149-55.
[Article in French]

Abstract

Objectives: Present clinical features of brucellosis in Lebanon.

Methods: Eighty-eight patients were seen at Hotel-Dieu de France Hospital of Beirut between 1994 and 2002. Diagnostic criteria were brucellar agglutinins at a titer; 1/160 with symptoms suggestive of brucellosis in the absence of other diagnosis and a therapeutic response.

Results: Out of the 88 hospitalized patients, 11 pediatric cases are noted. The disease is acute in 58 (66%), subacute in 28 (32%) and chronic in 2. The main presenting symptoms are fever, sweating, easy fatigability and diffuse aches. Osteoarticular involvement is the most prevalent complication (28%) and spondylitis is seen in 44% of these cases. Meningoencephalitis is the most frequent neurological manifestation. Among the haematological tests, relative lymphocytosis is significantly more frequent in children than adults (73% vs 19% ; p < 0,001) and in the acute form than the subacute (36% vs 7%; p < 0,001) whereas leucocytosis is more frequent in the subacute form (21% vs 7%; p < 0,01).

Conclusion: Brucellosis is still an endemic disease in Lebanon and should be systematically evoked in the case of prolonged fever, articular and neurological manifestations.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Agglutinins / blood
  • Anti-Bacterial Agents / therapeutic use
  • Brucella / immunology
  • Brucellosis / complications
  • Brucellosis / diagnosis*
  • Brucellosis / drug therapy*
  • Brucellosis / epidemiology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Lebanon / epidemiology
  • Male
  • Middle Aged
  • Retrospective Studies

Substances

  • Agglutinins
  • Anti-Bacterial Agents