Colorimetric determination of indolic drugs

Pak J Pharm Sci. 2005 Apr;18(2):48-51.

Abstract

A colorimetric method has been developed for the quantitative determination of the rescinnamine, reserpine upto (-10(-4M)), Yohimbine on complexation with bromothymol blue. The coloured complexes exhibit absorption maxima in the region 415-416 nm. The RSD (Relative Standard Deviation) of the method is 2.02%. The method is simple, easy, rapid and convenient for routine analysis of the indolic drugs.

MeSH terms

  • Bromthymol Blue / chemistry
  • Chloroform
  • Colorimetry / methods
  • Electrons
  • Indole Alkaloids / analysis
  • Indoles / analysis*
  • Indoles / chemistry
  • Molecular Conformation
  • Reproducibility of Results
  • Reserpine / analogs & derivatives
  • Reserpine / analysis
  • Solvents
  • Spectrophotometry, Ultraviolet / methods
  • Technology, Pharmaceutical / methods
  • Time Factors
  • Yohimbine / analysis

Substances

  • Indole Alkaloids
  • Indoles
  • Solvents
  • Yohimbine
  • Chloroform
  • Reserpine
  • rescinnamine
  • Bromthymol Blue