The first detection of CTX-M-14 extended-spectrum beta-lactamase among diverse beta-lactamase-producing Proteus mirabilis clinical isolates

Diagn Microbiol Infect Dis. 2006 Mar;54(3):237-9. doi: 10.1016/j.diagmicrobio.2005.09.013. Epub 2006 Jan 19.

Abstract

CTX-M-14- and -2-like extended-spectrum beta-lactamases were detected in 5 and 1 Proteus mirabilis isolates, respectively, among 92 non-duplicate strains tested from December 2002 to September 2003. This is the first report of the CTX-M-14 enzyme in P. mirabilis to the best of our knowledge and suggests that the CTX-M-type enzyme is gradually spreading to this species. bla(TEM), bla(SHV-1), and/or bla(OXA-10) alleles were also detected in 35 ampicillin-resistant isolates tested.

MeSH terms

  • Adult
  • Aged
  • DNA Fingerprinting
  • DNA, Bacterial / genetics
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Epidemiology
  • Proteus Infections / microbiology*
  • Proteus mirabilis / classification
  • Proteus mirabilis / drug effects
  • Proteus mirabilis / enzymology*
  • Proteus mirabilis / isolation & purification
  • beta-Lactam Resistance*
  • beta-Lactamases / analysis*
  • beta-Lactamases / genetics

Substances

  • DNA, Bacterial
  • beta-lactamase CTX-2
  • beta-lactamase CTX-M-14
  • beta-Lactamases