Cerebral ischemia associated with anticardiolipin antibodies

Acta Neurol Scand. 1992 Jun;85(6):412-7. doi: 10.1111/j.1600-0404.1992.tb06039.x.

Abstract

Eight patients, 3 with systemic lupus erythematosus (SLE) or "SLE-like" disease, 1 with sarcoidosis, and 4 with no connective tissue disease had transient ischemic attacks (TIA) or cerebral infarctions associated with high levels of anticardiolipin antibodies (ACA). Cerebral ischemic events included amaurosis fugax, recurrent hemispheric TIA, cerebral infarction, and multi-infarction dementia. Treatment with acetylsalicylic acid was ineffective in 3 patients. Warfarin, alone or in combination with dipyridamole or steroids, may reduce the risk of further cerebrovascular events.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antiphospholipid Syndrome / diagnosis
  • Antiphospholipid Syndrome / drug therapy
  • Antiphospholipid Syndrome / immunology*
  • Aspirin / administration & dosage
  • Autoantibodies / analysis*
  • Brain Ischemia / diagnosis
  • Brain Ischemia / drug therapy
  • Brain Ischemia / immunology*
  • Cardiolipins / immunology*
  • Cerebral Infarction / diagnosis
  • Cerebral Infarction / drug therapy
  • Cerebral Infarction / immunology
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Middle Aged
  • Neurologic Examination / drug effects
  • Prednisolone / administration & dosage
  • Warfarin / administration & dosage

Substances

  • Autoantibodies
  • Cardiolipins
  • Warfarin
  • Prednisolone
  • Aspirin