Abstract
The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 microg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Topical
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Animals
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Anti-Ulcer Agents / therapeutic use*
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Biomarkers / metabolism
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Cricetinae
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Fluorouracil / toxicity*
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Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use*
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Male
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Mesocricetus
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Mouth Mucosa / drug effects*
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Mouth Mucosa / metabolism
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Mouth Mucosa / pathology
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Oral Ulcer / chemically induced
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Oral Ulcer / drug therapy*
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Oral Ulcer / pathology
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Recombinant Proteins
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Stomatitis / chemically induced
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Stomatitis / drug therapy*
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Stomatitis / pathology
Substances
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Anti-Ulcer Agents
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Biomarkers
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Recombinant Proteins
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Granulocyte-Macrophage Colony-Stimulating Factor
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Fluorouracil