Polyplex-embedding in polyelectrolyte multilayers for gene delivery

Florent Meyer; Vincent Ball; Pierre Schaaf; Jean Claude Voegel; Joelle Ogier

doi:10.1016/j.bbamem.2005.11.015

Polyplex-embedding in polyelectrolyte multilayers for gene delivery

Biochim Biophys Acta. 2006 Mar;1758(3):419-22. doi: 10.1016/j.bbamem.2005.11.015. Epub 2005 Dec 27.

Authors

Florent Meyer¹, Vincent Ball, Pierre Schaaf, Jean Claude Voegel, Joelle Ogier

Affiliation

¹ Inserm Unité 595, 11 rue Humann, F-67085 Strasbourg, France.

PMID: 16413494
DOI: 10.1016/j.bbamem.2005.11.015

Abstract

In this work, incorporation of plasmid DNA, pre-complexed with PEI, into polyelectrolyte multilayers has been studied to further develop platforms for local gene delivery. Polyplex embedding in synthetic and naturally degradable architectures was efficient for transfection of human hepato-cellular carcinoma cells.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Hepatocellular
Cell Line, Tumor
DNA / chemistry
Electrolytes* / chemistry
Humans
Liver Neoplasms
Plasmids* / chemistry
Polyethyleneimine / chemistry*
Transfection / methods*

Substances

Electrolytes
Polyethyleneimine
DNA