Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives

Gwenaelle Desforges; Laurent Picot; Cyril Montagne; Valérie Thiéry; Thierry Besson; Benoit Joseph

doi:10.1080/14756360500212621

Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives

J Enzyme Inhib Med Chem. 2005 Dec;20(6):569-74. doi: 10.1080/14756360500212621.

Authors

Gwenaelle Desforges¹, Laurent Picot, Cyril Montagne, Valérie Thiéry, Thierry Besson, Benoit Joseph

Affiliation

¹ Laboratoire de Chimie Organique 1, UMR-CNRS 5181, Université Claude Bernard, Lyon 1, CPE, Bâtiment 308, 43 Boulevard du 11 Novembre 1918 69622, Villeurbanne cedex, France.

PMID: 16408792
DOI: 10.1080/14756360500212621

Abstract

Novel 1,3,9-triazacyclopenta[b]fluorene-4,10-diones and 1,3,9-triazacyclopenta[b]fluorene, analogue of ellipticine, were synthesised, and evaluated in vitro for their antiproliferative activity on various breast cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / drug therapy*
Carbazoles / chemical synthesis*
Carbazoles / chemistry
Carbazoles / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Female
Fluorenes / chemical synthesis*
Fluorenes / chemistry
Fluorenes / pharmacology*
Humans
Imidazoles / chemical synthesis*
Imidazoles / chemistry
Imidazoles / pharmacology*
In Vitro Techniques
Molecular Structure
Structure-Activity Relationship

Substances

Carbazoles
Fluorenes
Imidazoles