To study the reaction of amine with dairylide yellow pigment (PY14) used in electrophoretic display, especially the reaction mechanism between polyisobutylene imide (PIBI) and PY14, some amines were selected to react with PY14. At the same time, tetraethylene pentamine was treated with HCl. The zeta potential and IR of the above products were tested. Based on the zeta potential and IR frequency, the charge control intensities of different amines on PY14 were compared, and it is confirmed that the reaction of PY14 with amines is Lewis reaction, the charge control of secondary and primary amines with less steric obstacle is stronger. The PY14 zeta potential value reverse is due to the adsorption of bigger reverse ion.