Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bioimaging

Photochem Photobiol Sci. 2006 Jan;5(1):102-6. doi: 10.1039/b509843b. Epub 2005 Nov 11.

Abstract

We report here the synthesis and characterization of a new type of non-ionic blue fluorescent water-soluble chromophores specifically designed for two-photon absorption microscopy. The water solubility is induced by introduction of short oligo(ethylene glycol) monomethyl ether moieties. This work has led to low molecular weight dyes with efficient two-photon absorption cross sections and high fluorescence quantum yield in organic solvents as well as in aqueous solutions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biphenyl Compounds / chemical synthesis*
  • Biphenyl Compounds / chemistry*
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry*
  • Molecular Structure
  • Molecular Weight
  • Photons
  • Quantum Theory
  • Sensitivity and Specificity
  • Solubility
  • Spectrometry, Fluorescence
  • Stilbenes / chemical synthesis*
  • Stilbenes / chemistry*
  • Water / chemistry

Substances

  • 4,4'-bis(3',4',5'-tridodecyloxystilbene-4-yl)biphenyl
  • Biphenyl Compounds
  • Fluorescent Dyes
  • Stilbenes
  • Water