Presents an overview of leading areas of discovery in bio-fluid mechanics related to the pulmonary system, with particular reference to the airways. Areas briefly reviewed include airway gas dynamics, impedance studies, collapsible-tube studies, and airway liquid studies. Emphasis is placed on promising further directions, such as analysis of interacting fluid-mechanical or fluid-structure phenomena, multi-scale modeling across widely varying length and time scales, and integration of advanced simulations into respiratory investigation and pulmonary medicine.