Cyclodextrin-grafted polysaccharides as supramolecular carrier systems for naproxen

Héctor L Ramírez; Aymara Valdivia; Roberto Cao; Juan J Torres-Labandeira; Alex Fragoso; Reynaldo Villalonga

doi:10.1016/j.bmcl.2005.12.049

Cyclodextrin-grafted polysaccharides as supramolecular carrier systems for naproxen

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1499-501. doi: 10.1016/j.bmcl.2005.12.049. Epub 2005 Dec 28.

Authors

Héctor L Ramírez¹, Aymara Valdivia, Roberto Cao, Juan J Torres-Labandeira, Alex Fragoso, Reynaldo Villalonga

Affiliation

¹ Enzyme Technology Group, University of Matanzas, Matanzas 44740, Cuba.

PMID: 16386421
DOI: 10.1016/j.bmcl.2005.12.049

Abstract

Dextran, mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with beta-cyclodextrin moieties by reductive alkylation in the presence of sodium borohydride. These polymers were used as supramolecular carriers for naproxen, improving the "in vivo" anti-inflammatory properties of this drug.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Carboxymethylcellulose Sodium / chemistry*
Carcinogens / chemistry
Carrageenan / toxicity
Dextrans / chemistry*
Drug Carriers / chemistry*
Edema / chemically induced
Edema / drug therapy
Male
Mannans / chemistry*
Naproxen / chemistry*
Oxidation-Reduction
Periodic Acid
Rats
Rats, Wistar
beta-Cyclodextrins / chemistry*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Carcinogens
Dextrans
Drug Carriers
Mannans
beta-Cyclodextrins
Periodic Acid
Naproxen
Carrageenan
metaperiodate
betadex
Carboxymethylcellulose Sodium