Abstract
The so-called conformational diseases constitute a specific subtype of protein folding diseases that is characterized by abnormal aggregation of improperly folded polypeptides. This review describes a series of examples of such disorders and summarizes the present knowledge on their molecular pathophysiology and new therapeutic strategies.
MeSH terms
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Alzheimer Disease / physiopathology
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Amyloid / metabolism
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Amyotrophic Lateral Sclerosis / physiopathology
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Animals
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Humans
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Huntington Disease / physiopathology
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Multiprotein Complexes
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Neurodegenerative Diseases / physiopathology*
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Peptides / chemistry*
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Peptides / metabolism*
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Prion Diseases / physiopathology
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Prions / metabolism
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Protein Binding
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Protein Conformation
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Protein Denaturation
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Protein Folding
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alpha 1-Antitrypsin Deficiency / metabolism
Substances
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Amyloid
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Multiprotein Complexes
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Peptides
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Prions