[Diseases associated with protein aggregation]

Postepy Biochem. 2005;51(3):297-307.
[Article in Polish]

Abstract

The so-called conformational diseases constitute a specific subtype of protein folding diseases that is characterized by abnormal aggregation of improperly folded polypeptides. This review describes a series of examples of such disorders and summarizes the present knowledge on their molecular pathophysiology and new therapeutic strategies.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Alzheimer Disease / physiopathology
  • Amyloid / metabolism
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Animals
  • Humans
  • Huntington Disease / physiopathology
  • Multiprotein Complexes
  • Neurodegenerative Diseases / physiopathology*
  • Peptides / chemistry*
  • Peptides / metabolism*
  • Prion Diseases / physiopathology
  • Prions / metabolism
  • Protein Binding
  • Protein Conformation
  • Protein Denaturation
  • Protein Folding
  • alpha 1-Antitrypsin Deficiency / metabolism

Substances

  • Amyloid
  • Multiprotein Complexes
  • Peptides
  • Prions