Abstract
Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Infective Agents / pharmacology*
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Bacterial Proteins / genetics*
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Chloramphenicol / pharmacology
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DNA Helicases / genetics*
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DNA Replication / drug effects*
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DnaB Helicases
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Mutation
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Quinolones / pharmacology*
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Temperature
Substances
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Anti-Infective Agents
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Bacterial Proteins
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Quinolones
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Chloramphenicol
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DNA Helicases
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DnaB Helicases