Abstract
A Campylobacter jejuni 81-176 mutant in Cj0977 was fully motile but reduced >3 logs compared to the parent in invasion of intestinal epithelial cells in vitro. The mutant was also attenuated in a ferret diarrheal disease model. Expression of Cj0977 protein was dependent on a minimal flagella structure.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Bacterial Proteins / physiology*
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Campylobacter Infections / metabolism*
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Campylobacter jejuni / genetics*
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Campylobacter jejuni / pathogenicity
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Campylobacter jejuni / ultrastructure
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Disease Models, Animal
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Ferrets / microbiology
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Mutation
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Sigma Factor / physiology*
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Virulence / genetics
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Virulence Factors / genetics
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Virulence Factors / metabolism
Substances
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Bacterial Proteins
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FliA protein, Bacteria
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Sigma Factor
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Virulence Factors