Abstract
In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.
MeSH terms
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Animals
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Connective Tissue / pathology
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Disease Models, Animal
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Epithelial Cells / metabolism
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Epithelial Cells / pathology*
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Fibroblasts / pathology*
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Male
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Mice
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Models, Biological
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Mutation / genetics*
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Paracrine Communication
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / pathology
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Stromal Cells / pathology*
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Tumor Suppressor Protein p53 / genetics*
Substances
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Tumor Suppressor Protein p53