Under pressure: stromal fibroblasts change their ways

Cell. 2005 Dec 16;123(6):985-7. doi: 10.1016/j.cell.2005.11.029.

Abstract

In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Connective Tissue / pathology
  • Disease Models, Animal
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology*
  • Fibroblasts / pathology*
  • Male
  • Mice
  • Models, Biological
  • Mutation / genetics*
  • Paracrine Communication
  • Prostatic Neoplasms / genetics
  • Prostatic Neoplasms / pathology
  • Stromal Cells / pathology*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • Tumor Suppressor Protein p53