Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

Chem Commun (Camb). 2005 Nov 28:(44):5563-5. doi: 10.1039/b510709a. Epub 2005 Oct 11.

Abstract

A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidohydrolases / antagonists & inhibitors*
  • Amidohydrolases / metabolism
  • Catalysis
  • Cyclization
  • Hydrolases / antagonists & inhibitors*
  • Hydrolases / metabolism
  • Molecular Structure
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology*
  • Sulfonic Acids / chemical synthesis
  • Sulfonic Acids / chemistry*

Substances

  • Protease Inhibitors
  • Sulfonic Acids
  • Hydrolases
  • Amidohydrolases
  • dimethylargininase
  • arginine deiminase